The positive correlation of levels of BACE1, phosphorylated eIF2α, and amyloid load in human brain along with the significant increase of BACE1 and phospho-eIF2α levels in AD brains compared to non-demented controls [22] suggests the eIF2α phosphorylation pathway might be relevant to AD pathogenesis. The gene discussed is EIF2A; the disease is Alzheimer disease.