APP and Alzheimer disease: Moreover, YFP fluorescence in brain sections from BACE1-YFP; 5XFAD mice demonstrated marked accumulation of BACE1-YFP in swollen dystrophic neurites surrounding amyloid deposits in a pattern identical to endogenous BACE1 immunostaining near plaques in APP transgenic and AD brains (Fig. 5C; [24], [26]).