This mouse line expresses two linked transgenes, both driven by the Thy1 promoter: 1) the 695 amino acid isoform of human APP with three famililal Alzheimer’s disease (FAD) linked mutations called Swedish (K670N, M671L) [62], Florida (I716V) [63] and London (V717I) [64]; 2) human PS1 with the two FAD mutations M146L and L286V [65]. This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.