These data suggest that CXCR3 is important in the recruitment of neutrophils to the inflammatory site following DSS challenge, in line with the findings that show that CXCR3 blockade limits neutrophil accumulation in the inflamed joints of rats with arthritis [43] and that CXCR3 is expressed by neutrophils in inflammatory sites [21], [44]. This evidence concerns the gene CXCR3 and arthritic joint disease.