CD28 and neoplasm: Among these predicted genes integrated or closed to the integration site, we identified several tumor-associated genes, including PRDX5, CD28, ROCK2, RHOH, TIMP3 and DAPK1, etc. As shown in Table 1, the transcripts type D and E were only detected in CxCa and most of their integration loci were located in or close to the fragile sites of FRA13C, FRA22B, FRA2I and FRA13A.