Among these predicted genes integrated or closed to the integration site, we identified several tumor-associated genes, including PRDX5, CD28, ROCK2, RHOH, TIMP3 and DAPK1, etc. As shown in Table 1, the transcripts type D and E were only detected in CxCa and most of their integration loci were located in or close to the fragile sites of FRA13C, FRA22B, FRA2I and FRA13A. The gene discussed is ROCK2; the disease is neoplasm.