[17], [18], [34]. Low Klotho levels may therefore have led to sinoatrial dysfunction secondary to disturbed ion channels regulation in the cardiac peacemaker cells. Through protecting against AF, which is mostly attributed to senescence processes, Klotho appears to have anti-aging properties. With decreasing Klotho tertiles and therefore increasing AF prevalance, the treating physicians prescribed beta-, renin-angiotensin-aldosteron-blockers and statins more frequently (Table 1). Here, KL is linked to atrial fibrillation.