In the present study, we found that the knockdown of Nrf2 expression through specific siRNA transfection in both microglia and astrocytes decreased the protection induced by SalB after MPP+ or LPS insults, suggesting that Nrf2 participates in prevention of inflammation in PD by a mechanism that involves microglia and factors secreted by astrocytes, which is in agreement with other studies [59], [60]. The gene discussed is NFE2L2; the disease is Parkinson disease.