To further characterize the CXCR4–CXCL12–CXCR7 pathway in renal cancer cells, the induction of the mTOR targets P70S6K and 4EBP1 was evaluated in the presence of anti-CXCR4 (12G5), Peptide R and anti-CXCR7 (11G8). The gene discussed is CXCL12; the disease is renal carcinoma.