Intriguingly, downregulation of these miRNAs was accompanied by a concomitant upregulation of their targets CCND1, TACC3, MAFB, FGFR3, and MYC, which were also the oncogenes upregulated by the most recurrent IgH translocations in nonhyperdiploid MM. The gene discussed is CCND1; the disease is Miyoshi myopathy.