Hyperdiploid myeloma (H-MM) is characterized by multiple trisomies involving odd number chromosomes except chromosome 13 and a lower prevalence of primary translocation involving the immunoglobulin heavy chain (IgH) locus at 14q32, whereas nonhyperdiploid myeloma (NH-MM) is characterized by IgH translocations, most commonly t(4; 14) which translocates MMSET and FGFR3 at 4p16.3 to the IgH enhancers, t(11; 14) involving CCND1, and t(14; 16) involving MAF [15, 16]. Here, NSD2 is linked to Miyoshi myopathy.