We are also in discordance more with the results of Sallakci et al. [3], which was conducted on another smaller Turkish population, than those of Gunesacar et al. [20], where there were absent associations between the CTLA-4 +49 A/G polymorphism and susceptibility to BD, although they observed that BD patients with ocular involvement and erythema nodosum-like lesions had higher frequencies of both the A allele and the AA genotype at position 49 of exon-1, so they consider CTLA-4 as a disease-modifying rather than a susceptibility gene for BD. The gene discussed is CTLA4; the disease is Behcet disease.