PAPPA2 and preeclampsia: Out of the 350 differentially expressed genes in women with preeclampsia and 554 genes in women with the HELLP syndrome, 224 genes (including LEP, CGB, LHB, INHA, SIGLEC6, PAPPA2, TREM1, and FLT1) changed in the same direction (elevated or reduced) in both syndromes.