The allelic variants of the innate immune system, the toll-like receptor-4 (TLR-4) and the NOD2 gene (an apoptosis regulator) variants, were investigated by van Rijn et al. 6 months after delivery in primiparous women with a history of an early-onset preeclampsia (n = 340) of whom 177 developed the HELLP syndrome; 113 women with an uneventful pregnancy were controls [52]. Here, TLR4 is linked to HELLP syndrome.