In accordance with the altered trophoblast pathophysiology in early-onset preeclampsia, many of the most differentially regulated genes in women with preeclampsia (LEP, CGB, LHB, INHA, SIGLEC6, PAPPA2, and FLT1) have predominant or unique expression in the syncytiotrophoblasts [91]. Here, PAPPA2 is linked to preeclampsia.