We have previously demonstrated the injurious role of infiltrating immune cells in the pathogenesis of post-ischemic brain injury in mice[5], and the beneficial effects of IVIg treatment on the levels of inflammatory endothelial and leukocyte adhesion molecules such as ICAM-1, CD11a, and CD11b in a mouse model of ischemic stroke[2]. The gene discussed is ICAM1; the disease is ischemic stroke.