The diagnosis of Xp11.2 translocation RCC is suspected based on clinical information, histology and immunochemical features, however, it is confirmed by the detection of chromosome translocation involving TFE3 gene at Xp11.2 using different methods.13 In this regard nuclear immunoreactivity for TFE3 protein cells arranged mostly papillary and focally in solid/alveolar patterns. This evidence concerns the gene TFE3 and renal cell carcinoma.