SQSTM1 and cancer: The up-regulated proteins Sequestosome1 (SQSTM1) and Protein kinase C delta-binding protein (PRKCDBP) were involved in promoting apoptosis.29,30 Although the up-regulated protein SCO1 was not directly involved in the regulated network (Figure 4A), the recent research has reported that SCO1 caused apoptosis by inducing reactive oxygen species in mitochondria.31 Furthermore, up-regulated mitochondrial proteins (SCO1, SLC25A11) and down-regulated GPX1 might indicate that the cancer cells were suffered from oxidation stress induced by 2 Gy carbon irradiation.