NTN1 and diabetic kidney disease: Using a different approach, Eunyong Tak et al. also showed the elevated levels of albuminuria, glomerular filtration rate, and severe loss of kidney function in partial netrin-1 deficient (Ntrn1 ± mice) diabetic mice, whereas administration of recombinant netrin-1 was associated with attenuated albuminuria and improved histological score for diabetic nephropathy compared to control mice [105].