For the pathogenesis of autoimmune disease, such as systemic lupus erythematosus (SLE), the first report on role of DNA methylation was made during early 1980s with certain medications, such as hydralazine and procainamide inhibiting DNA methyltransferase1 (DNMT1) enzyme activity in CD4+ T cells [52], and was subsequently demonstrated by several studies [53, 54]. This evidence concerns the gene CD4 and systemic lupus erythematosus.