These inflammatory stimulators provoke aberrant expression of miRNAs in several chronic inflammatory diseases; for example, miR-146a that targets COX2 gene is highly increased in response to the stimulation of inflammatory cytokines in several cell types from COPD patients [66], whereas it has reduced levels in CD4+ T- and CD8+ T-cells in patients with severe asthma [67]. This evidence concerns the gene CD4 and asthma.