NFE2L2 and myeloid sarcoma: However, clinical benefits are believed to be related, in part, to activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway14,15 and modulation of the expression of pro- and anti-inflammatory cytokines16, , –19 and phase 2 detoxification enzymes.15,18 Inflammation and neurodegenerative processes are prominent early in the course of MS, so agents with putative dual anti-inflammatory and neuroprotective effects, such as delayed-release DMF, may be particularly useful.