In this context, the predicted suppression of the transcriptional repressor OSR2 by all 4 stimuli analyzed in this study (as well as the influence of 2 or 3 stimuli on the genes TGF- β, RELA, GLI2, WNT5B, and WNT9A) may well indicate the existence and/or importance of respective cross-talk among these mediators in RA-SFBs. This evidence concerns the gene RELA and rheumatoid arthritis.