For example, NetGenerator was capable of modeling the response following the initial stimulation of RA-SFBs by TNF- α, IL-1 β, TGF- β, and PDGF-D, e.g., sequential activation of signaling molecules/transcription factors (see 13/24 potential transcription factors in Table 5) and/or protein secretion of (growth) factors (8/24 potential factors in Table 5), which may support enduring activation of RA-SFBs [22] and persistence of joint inflammation and destruction in RA [16]. This evidence concerns the gene PDGFD and rheumatoid arthritis.