IFIH1 and dermatomyositis: Studies based in East-Asia have identified anti-MDA5 (anti-Melanoma differentiation associated gene 5) autoantibodies in 19 to 35% of adult dermatomyositis (DM) patients[2,3], where it is associated with clinically amyopathic myositis (81%), rapidly progressive ILD (74%) and a poor prognosis[4,5].