CCL26 and gastroesophageal reflux disease: For patients who have Th2-cytokine driven esophageal eosinophilia and gastroesophageal reflux, in contrast, eotaxin-3 expression in the distal esophagus might be suppressed by reflux, while eotaxin-3 expression remains high in the proximal esophagus where reflux exposure is minimal (Figure 9C).