In the present study, we have generated a DIC post infarction mouse model and evaluated the response of the injured myocardium to the transplanted ES and iPS cells as well as identified signaling molecules, including Notch-1, Hes1, PTEN, and Akt, which play a pivotal role in the cytoprotective mechanisms conferred by our transplanted stem cells. This evidence concerns the gene HES1 and infarction.