In conclusion, the major findings of the present study include the following for the first time: In the DIC post-MI heart, following ES and iPS cell transplantation, (1) apoptosis was significantly inhibited, (2) Notch-1 and Hes-1 expression were significantly increased, (3) fibrosis and MMP-9 expression were significantly diminished, (4) Akt activation was significantly enhanced and PTEN levels were abolished, and (5) cardiac dysfunction was mitigated. The gene discussed is NOTCH1; the disease is myocardial infarction.