In addition to six well-known and emerging cancer genes (TP53, CTNNB1, ARID1A, ARID2, AXIN1 and MLL3) in HCC [1], [2], [4], [6], [15], five genes (LRP1B, USH2A, ALB, GPR98 and COL11A1) were significantly mutated in HCC in the original mutation datasets analyzed in this study [4], [11] and our integrated results confirmed their high mutation frequencies. The gene discussed is AXIN1; the disease is cancer.