There was also a trend toward higher rates of metastasis in HCC with mutations of six pathways, including the p53 signaling pathway, PI3K-Akt signaling pathway, axon guidance, NF-kappa B signaling pathway, lysine degradation and carbohydrate digestion and absorption (60% vs. 30%, 92% vs. 68%, 64% vs. 31%, 48% vs. 20%, 36% vs. 12%, 36% vs. 14%; p = 0.014, p = 0.018, p = 0.007, p = 0.015, p = 0.018, p = 0.030, respectively). Here, PIK3CA is linked to hepatocellular carcinoma.