There was also a trend toward higher rates of metastasis in HCC with ATM, ATR, MDN1 and RELN gene mutations (12% vs. 0%, 12% vs. 1%, 12% vs. 1%, 12% vs. 1%; p = 0.015, p = 0.049, p = 0.049, p = 0.049, respectively). Here, ATM is linked to hepatocellular carcinoma.