LEPR and cancer: Specifically, among the top 50 mutated genes with the highest betweenness coefficients, 11 well-known and emerging cancer genes (TP53, CTNNB1, PIK3CA, EGFR, IGF1R, JAK2, STAT1, NFKB1, LEPR, SOCS3, and HRAS) were observed in HCC [2], [15], [28], [29], [30].