Tovar-y-Romo and Tapia showed the importance of the PI3K/AKT survival pathway role, as well as the inhibition of p38 MAPK (p38 mitogen activated protein kinase)—stress-activated protein kinase, in the protective mechanism exerted by VEGF against excitotoxic spinal motor neuron death in vivo, thus suggesting that VEGFR-2, the p38 MAPK, and PI3K pathway constitute appealing therapeutic targets for ALS [208]. This evidence concerns the gene VEGFA and amyotrophic lateral sclerosis.