VEGFA and amyotrophic lateral sclerosis: A study based on Swedish, English, Belgian, Russian, and American patients displayed an association between 2 haplotypes determined by 3 single-nucleotide polymorphisms (SNPS) −2.578 C/A, −1.154 L/C, and −634 G/C—in the VEGF upstream promoter/leader sequence of the VEGF gene with an increased risk of ALS [40, 226–228].