BRAF and thyroid nodule: Since in some cases of thyroid nodule biopsy, the specimens for cytology assessment do not contain enough cells with mutated BRAF and the result obtained is negative despite the mutation in thyroid nodule, currently there are indications to re-evaluate BRAF mutation in follow-up biopsy performed a few months later, especially when the nodule presents ultrasonography features of malignancy and cytology assessment of focal thyroid lesion gives non-diagnostic results, there are signs of atypia or the nodule is of benign nature[11].