TSHR and thyroid gland papillary carcinoma: The genes controlling the proliferation of cells, which undergo hypermethylation in the papillary carcinoma include TIMP-3 (tissue inhibitor of metalloproteinase-3, inhibitor of extracellular metalloproteinases), DAPK (calcium-dependent protein kinase), taking part in programmed cell death, SLC5A8 (sodium symporter), DNA repair genes (hMLH1, PCNA) and thyroid-specific genes (NIS-sodium-iodine symporter, TSHR- thyroid stimulating hormone receptor).