In these trials, lymphocytes [either tumor-infiltrating lymphocytes (TIL) or gene-engineered PBL] are often expanded with high dose IL-2 (6000 IU/ml) and soluble OKT3 (anti-CD3), or are expanded with magnetic beads decorated with CD3 and CD28 agonists (126, 127). Here, CD28 is linked to neoplasm.