Though the mechanism leading to the formation of NFTs is still elusive, it has been well recognized that an imbalanced regulation in protein kinases and protein phosphatases is the direct cause for the AD-like tau hyperphosphorylation (Gong et al., 2000; Planel et al., 2000; Liu et al., 2005; Qian et al., 2010). Here, MAPT is linked to Alzheimer disease.