These include interactions between GSK-3β and components of the plaque-producing amyloid system (Takashima et al., 1993; Aplin et al., 1996), and interactions of GSK-3β with presenilin (Takashima et al., 1998; Gantier et al., 2000; Dolma et al., 2014) and other AD-associated proteins (Grimes and Jope, 2001; Hohman et al., 2014). Here, GSK3B is linked to Alzheimer disease.