We found that I2PP2A protein level was significantly increased in htau transgenic mice compared with the wild-type mice (Figure 1A), while intracranial injection of Lenti - siI2PP2A into the hippocampus of htau transgenic mice, a recognized AD-like animal model for tau pathology (Polydoro et al., 2009), reduced the I2PP2A level to ~45% of the control level at 4 weeks after the injection (Figure 1B). The gene discussed is SET; the disease is Alzheimer disease.