TREM2 and Alzheimer disease: While dysfunction along the miRNA-34a-TREM2-TYOBP(DAP12) axis may be a particularly strong contributor to phagocytosis deficits and amyloidogenesis in AD it is important to note that other miRNA-mRNA pairings may also be involved in Aβ42 clearance and altered innate-immune responses in this complex genetic regulatory network.