Local NO may also reflect activity in blood vessels (from endothelial or eNOS) or inducible NO synthase (iNOS), with increased NO being associated with inflammatory and neurodegenerative diseases (Steinert et al., 2010; Nakamura et al., 2013) as well as following prolonged synaptic activity (Brenman et al., 1996; Holscher, 1997; Steinert et al., 2008, 2011). The gene discussed is NOS2; the disease is neurodegenerative disease.