Consistent with the view that KV1.1 is a promising antiepileptic target, KV1.1 knockout mice develop epilepsy (Wenzel et al., 2007) and lentiviral overexpression of KV1.1 ameliorates seizures in an animal model of neocortical epilepsy (Wykes et al., 2012). Here, KCNA1 is linked to epilepsy.