CHEK2 and Familial prostate cancer: Dong found 28 CHEK2 germline mutations among 578 men with prostate cancer, suggesting that CHEK2 mutations play a role in prostate cancer development [13], and Cybulski found common mutations, such as 1100delC, IVS2 + 1G > A and I157T, in families with hereditary prostate cancer [14].