BRCA1 and breast cancer: These variants could not explain the high familiarity of breast cancer in this family and we, therefore, conducted on III-4 the Multiplex Ligation-dependent Probe Amplification analysis (MLPA) for deletions/duplications of all BRCA1/2 exons with BRCA1-P002-C2 and BRCA2-P045-B3 (MRC Holland, Amsterdam, the Netherlands).