CHEK2 and breast carcinoma: In particular, the BRCA2-P045 kit contains probes for all the exons of BRCA2 and three additional probes for the CHEK2 gene: a probe for the promoter region, a probe specific to the 1100delC mutation [9] and a probe for exon 9, whose deletion has been detected in families with hereditary prostate and breast cancer [19,20].