The prognosis of all tumor subgroups with EGFR IHC low expression (0 ~ 2+) was promising than the one of high expression groups (3+) by log-rank analysis (Tables 1, 2, 3).Dual-color FISH analysis was carried out to evaluate for the gene amplification in the tumor lesions by the number of signals in each cell related to EGFR and to the centromeric region of chromosome 7. The gene discussed is EGFR; the disease is neoplasm.