TNF and Pleural effusion: It is reported that adenosine deaminase (ADA), tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), interlukine-12 (IL-12), interlukine-18 (IL-18), interlukine-10 (IL-10), interlukine-27 (IL-27), Immunosuppressive acidic protein (IAP), and soluble IL-2 receptor could serve as differential diagnosis biomarkers for pleural effusion caused by TB or malignant diseases [7,11,12].