GSK3B and familial pancreatic carcinoma: However, very few reports addressed the role of the alpha isoform in cancer cells growth/survival: so far, NFkB-dependent pro-survival effect has been demonstrated to be mediated either by GSK3A or GSK3B in pancreatic cancer cells [9] whereas GSK3A, but not GSK3B, has been identified as a therapeutic target in melanoma [15].