In order to further demonstrate that miR-204 induced the loss of SOX4 suppressed proliferation and invasion of gastric cancer cells, cells were transfected with miR-204 mimics and SOX4 over-expression vector together and the results showed that the suppression of migration, invasion and proliferation by miR-204 was attenuated (Figure S4). The gene discussed is SOX4; the disease is gastric cancer.