Given the growing understand for roles for FOXO proteins as negative regulators of cancer progression [31], [32], and a recent study showing that up-regulation of ANXA8 by FOXO4 inhibits the cell migratory and metastatic characteristics of cholangiocarcinoma cells [33], we focused on the possible role of FOXO4 as a potential metastasis suppressor. This evidence concerns the gene ANXA8 and cancer.