A study by Zhang et al. [20] demonstrates that FOXO1 inhibits CaP cell motility and invasiveness by preventing RUNX2 from binding to and transcriptionally activating progression genes such as OP, IL8, VEGF and MMP13. Although some redundant roles for FOXO proteins are implied by the finding that spontaneous thymic lymphomas and systemic hemangiomas are induced only upon the combined deletion of FOXO1, FOXO3 and FOXO4 [21], there is evidence from chromatin immunoprecipitation-sequencing (ChIP-seq) studies on FOXO1 and FOXO3a of both common and non-overlapping gene targets [22], [23]. This evidence concerns the gene FOXO1 and thymus lymphoma.