Interestingly and contrary to previous studies that analyzed Miz-1 regulation of specific candidate genes [7], [8], [10], [12]–[14], which described Miz-1 binding localized to core promoter initiator element (Inr) sequences in cancer cells, the global functional genomics analysis in hESCs demonstrated that the distribution of Miz-1 binding is predominantly localized to regions more than 1000 bases upstream of the transcriptional start sites of target genes [9]. Here, ZBTB17 is linked to cancer.