Whereas perpetual replicative capacity is directly linked to canonical telomerase activities [47], other aspects of cancer cell biology appear attributable to telomerase independent functions of TERT, including transcriptional modulation of Wnt β-catenin signaling [23], or RNA polymerase activity when TERT is complexed with the RNA component of mitochondrial RNA processing endoribonuclease (RMRP) [48]. Here, TERT is linked to cancer.