HLA-DRB1 and malaria: Although T1 functions as a T cell epitope in DR4 haplotype malaria-immune individuals [19], [31] we do not expect significant T cell responses to T1 in DR4 transgenic mice immunized with T1BT for two reasons: (i) in previous studies, a DR4 individual immunized with a construct containing T1BT* developed T cell response to T* but not to T1 [36], [38] and (ii) contrary to QNT-5 and QNT-Y (IC50 ∼25 and ∼500 respectively, Table 2), T1 binds very weakly to DRβ1*04:01 (IC50 ∼18000 nM, not shown).