As a consequence of these adverse effects, cancer cells depend on the expression of aldehyde defence enzymes, namely glyoxalase I (GLO1, EC 4.4.1.5) and –II (GLO2, EC 3.1.2.6) also called hydroxyacyl glutathione hydrolase (HAGH) [23] to avoid excessive aldehyde stress and fructosamine-3-kinase (FN3K, EC 2.7.1.171) [24] to prevent AGE-accumulation. This evidence concerns the gene HAGH and cancer.