The view that kidney receptors are associated with heart receptors in the cardiac structural and electric remodeling receives further support from the observation that elimination of AT1R in mice reduces cardiac hypertrophy and the risk of hypertension [49], and also from the observation that primary renal dysfunction in rats is associated with an augmented risk of congestive cardiac failure in simultaneous alterations that constitute a cardiorenal syndrome [53]. This evidence concerns the gene AGTR1 and congestive heart failure.