MC1R and melanoma: These genes are mainly involved in melanogenesis (MC1R, ASIP, TYR, TYRP1, and SLC45A2) and melanocyte differentiation (MITF, KIT, and EDNRB) [8–12].Recently, variants in other pathways, such as DNA repair, genome maintenance integrity, and immunological pathways (TERT-CLPTM1, CASP8, ATM, and MX2), have also been linked to melanoma predisposition [13–17].