The alteration of antioxidant enzymes GPx and SOD levels in the diabetic rats could be attributed to peroxidative damage of the tissues caused by streptozotocin-induced hyperglycemia [58], while supplementation with antioxidants contributed to maintaining the optimum condition of enzyme activity in the cellular organelles, by protecting them from peroxidation in chronic diabetes. Here, SOD1 is linked to Hyperglycemia.