Considering that tumor-associated macrophages (TAM) are known to enhance local production of VEGF (88) and galectin-3 was shown to be necessary for optimal pro-tumor macrophage polarization (89), Machado et al. have used an interesting approach to study the role of galectin-3 in TAM-mediated tumor angiogenesis. The gene discussed is LGALS3; the disease is neoplasm.