In this regard, exogenous or tumor-derived galectin-3 was shown to increase melanoma and colon cancer cells homotypic and heterotypic adhesions by interaction with oncofetal Thomsen–Friedenreich carbohydrate on the cancer-associated transmembrane mucin protein (MUC1) (21, 45, 73). The gene discussed is LGALS3; the disease is malignant colon neoplasm.