Afterward, the group revealed that galectin-3 overexpression on CML cells promotes its paracrine growth by decreasing the action of the SERPINA1–albumin complex growth inhibitor, a serine protease inhibitor involved in various proteolytic processes on the cell surface and on the ECM (15). This evidence concerns the gene LGALS3 and chronic myelogenous leukemia, BCR-ABL1 positive.