TGFB1 and Increased total eosinophil count: In neutrophilic asthma, another subtype of severe steroid refractory asthma characterized by Th17-mediated neutrophilic inflammation and the absence of airway eosinophilia, airway remodeling may result from EMT induced by TGFβ1 released from elastase-stimulated bronchial smooth muscle cells and/or dendritic cells [85].