CYP27B1 and breast carcinoma: However, clinical data on CYP27B1 expression in breast cancer is inconsistent (Segersten et al., 2005; Townsend et al., 2005; de Lyra et al., 2006; McCarthy et al., 2009; Lopes et al., 2010) and less than 2% of breast cancers annotated in The Cancer Genome Atlas datasets exhibit genomic alterations in CYP27B1.