VDR and neoplasm: In addition, the ENCODE project (http://genome.ucsc.edu/ENCODE/cellTypes.html) includes several breast cancer cell lines (MCF-7, MDA-MB-231, T47-D) which may provide relevant genomic information on nuclear receptor signaling The continued use of complex models such as tumor explants for vitamin D studies is desirable given the expression of VDR in most cell types and the critical interactions between tumor cells and their stromal microenvironment.