Notably, Chuvash polycythemia patients, who have high HIF2α expression, also have increased incidence of thrombotic events, major bleeding episodes, and premature mortality, suggesting that there are probably similar mechanisms operating in Chuvash polycythemia patients and the Irp1-/- mouse models (Gordeuk and Prchal, 2006). Here, ACO1 is linked to polycythemia.