MTOR and breast carcinoma: Naphthazarin, a naphthoquinone compound, is a microtubule depolymerising agent that induces cell death by activating apoptosis and autophagy13, and plumbagin induces G2-M arrest and autophagic cell death by inhibiting the AKT/mTOR (mammalian target of rapamycin) pathway in breast cancer cells14.