Another study examined SNPs in the 3′ untranslated region of TGFBR1 and found that 29 of 138 patients with MSI-negative CRC showed ASE, with 14 of the 29 (48%) having a *6A/*9A genotype and clear enrichment of ASE in familial cases [10]. The gene discussed is TGFBR1; the disease is colorectal carcinoma.