The bidirectional crosstalk between the AR and AKT pathways has been shown to fuel the growth of castration-resistant PCa cells (Wang et al. 2007, Kaarbo et al. 2010, Chandarlapaty et al. 2011, Mulholland et al. 2011) and phospho-ERK has been identified as a potential link between the PI3K/AKT pathway and the AR axis (Thomas et al. 2013). The gene discussed is AR; the disease is posterior cortical atrophy.