LRP2 and Donnai-Barrow syndrome: Our observations in the megalin-deficient mice thus appear to be more analogous to observations from the Donnai-Barrow Syndrome patients with respect to the severity as well as progression of the myopia (Patel et al. 2007; Kantarci et al. 2008; Pober et al. 2009; Schrauwen et al. 2013).