With consistent to the above findings, immunohistochemistry analysis of tumor tissue treated with Aea4 or Aea25 revealed that inhibition of FGFR1 produces a subsequent reduction in phosphorylation of ERK/Akt and the anti-apoptotic protein Bcl-2, indicating that the apoptotic effects of Aea4 or Aea25 treatment result directly from an inhibition of the cell survival pathway regulated by the FGFR1. This evidence concerns the gene FGFR1 and neoplasm.