To validate our findings on LASP1 overexpression in a subset of PCa samples on protein level, we investigated the LASP1 protein expression pattern by immuno-histochemistry (IHC) in specimens from 15 benign prostatic hyperplasias (BPH), 161 high-risk PCa derived from patients with pre-treatment PSA >20 ng/ml who underwent radical prostatectomy, and 17 corresponding lymph node metastases (LNM). Here, PROS1 is linked to posterior cortical atrophy.